New Members

[07/20/2017], University of Central Florida , Orlando,, USA, The Advanced Research Computing Center (ARCC) at the University of Central Florida houses high performance computing resources for use in research by faculty across campus. Research supported by the ARCC covers a variety of different disciplines, including Engineering, Modeling and Simulation, Optics, Nanoscience, and many others. The ARCC staff also pursues research in machine learning and visualization, as well as information technology. Currently, the center houses a high performance computing system known as Stokes, which is used to help support and drive research within the university.

[05/02/2017], Shandong University, Shandong Sheng, China Founded in 1901, Shandong University, based in Jinan, China, is the nation’s largest public university. It has prepared over 400,000 individuals in a variety of specialties, and has been making significant contributions to the country’s economic and social development. The growth of the university has allowed it to rise to the forefront of many fields in China. They continually develop new disciplines such as crystal materials, cardiovascular functional recovery, and new drug manufacturing to stay on the cutting edge of scientific research. Many of these newly formed disciplines have quickly risen to the first-class level within the country, and some are even know abroad.

[02/17/2017], University of Porto, Praça de Gomes Teixeira, Portugal The University of Porto, founded in 1911, is a leading scientific and research institution located in Portugal. The university is internationally recognized for the quality of research it produces, and is consistently ranked among the 150 best European universities. It is an important driver of economic, social, and scientific development within Portugal, and strives to be a strong partner of the business community. By combining quality teaching with a focus on market needs, the university strives to actively participate in, and encourage, the progress of communities in which it operates.

[05/24/2016], Marche Polytech University, Ancona, Italy, The Department of Life and Environmental Sciences was established in 2011 by merging a number of laboratories involved in a wide spectrum of fundamental and applied research topics. The department is a center of excellence of the Università Politecnica delle Marche and includes more than 100 scientists and technicians that conduct research in areas such as analytical and organic chemistry, biophysics, cellular and molecular biology, biochemistry and genetics, microbiology and biotechnology, viral, prokaryotic, fungal, algal, plant and animal systematics, physiology and reproduction, marine biology, ecology, eco-toxicology, oceanography, Earth sciences, risk reduction and civil protection.

[05/12/2016], University of Buenos Aires, Buenos Aires, Argentina, Buenos Aires University consists of thirteen colleges/schools, dozens of research institutes, and two secondary schools, offering more than 100 undergraduate majors. There is a teaching staff of 30,000 teachers, and approximately 300,000 students; 30% of scientific research in Argentina takes place at UBA. Standard undergraduate studies last approximately 5 years. Buenos Aires University offers several graduate programmers, masters, PhDs, and specialization courses as well.

[05/12/2016], Queen's University, Kingston, Canada, The mission of Queen's University has been articulated in a number of different forms and formats over the past decade. In all of the presentations, the key elements have remained constant: The University will build on the strength that is Queen's - students, faculty, staff and alumni - to be among the best of internationally known universities in Canada, recognized for: •the exceptional quality of undergraduate and graduate students and programs in the arts, sciences and professions; •the intellectual power and value of research and scholarship by faculty members and students; •the exemplary service of the University and that of its graduates to the community and the nation and the community of nations.

[04/28/2016], University of Leuven, Leuven, Belgium KU Leuven is a research-intensive, internationally oriented university that carries out both fundamental and applied research. It is strongly inter- and multidisciplinary in focus and strives for international excellence. To this end, KU Leuven works together actively with its research partners at home and abroad.KU Leuven encourages personal initiative and critical reflection in a culture of idea exchange, cooperation, solidarity and academic freedom.

[03/07/2016], Mayo Clinic , Rochester, MN,, USA, Mayo Clinic is the first and largest integrated nonprofit medical group practice in the world, employing more than 3,800 physicians and scientists, as well as 50,900 allied health staff. Based out of Rochester, MN, the Mayo Clinic’s mission is “to inspire hope and contribute to health and well-being by providing the best care to every patient through integrated clinical practice, education, and research.” The practice specializes in treating difficult cases through tertiary care, and spends over $500 million a year on research. It was also recognized as one of the best hospitals in the U.S. for 2015-2016 by U.S. News & World Report.

[03/02/2016], Czech Technical University, Prague,, Czech Republic, The Czech Technical University in Prague (CTU) is an internationally recognized higher education and research institution with more than 300 years of tradition and excellence. CTU is a leading technical research university with a large focus on cutting edge science and engineering, paired with a high-quality technical education. With 8 departments each focused on an engineering specialty, the university educates modern specialists, scientists, and managers who are dynamic, flexible, and able to rapidly adapt to the requirements of the market.

[02/10/2016], CERB , Baugy,, France, Located in Baugy, France, CERB was founded in 1973 and has developed into a leading international contract research organization (CRO) in the fields of pre-clinical pharmacology and toxicology. Taking on the challenges of modern drug development, CERB has created a distinctive image as a leading major service provider to the pharmaceutical industry in the context of innovative bio-medical research. CERB takes advantage of its sophisticated synergy between pharmacology and toxicology resources to provide complete pre-phase I packages for new molecules in an economic and timely manner

[01/07/2016], Goergen Institute for Data Science (GIDS), Rochester NY, USA The GIDS supports faculty research, particularly collaborative public-private research partnerships spanning several domains, such as developing health care breakthroughs, improving our knowledge of how the brain works, and creating tools and systems to efficiently use data. The GIDS is working to build strategic alliances and business partnerships among the academic, government, and business communities, leveraging University of Rochester expertise.

[10/06/2015], Dresden University of Technology, Dresden, Germany, Dresden University of Technology is one of eleven German universities that were identified as an “excellent university", and includes over 37,000 students with 14 institutions offering a wide range of academic programs. The Institute of Biomedical Engineering focuses on the early detection, diagnosis, and treatment of life-threatening cardiovascular disease. With a strong focus on research.

[10/06/2015], Biomedical Systems, St. Louis, MO , USA, Biomedical Systems has set the health care industry standard by providing innovative approaches to non-invasive diagnostic services, clinical trials, and products. They provide their clients with the ability to increase cost efficiencies and bring studies to database lock on an advanced timeline by combining over 20 modalities in one study. Biomedical Systems' pioneering spirit is based on a strong history as a privately held company that focuses on clients and people.

[09/15/2015], VivaQuant LLC, St. Paul MN, USA, VivaQuant provides products, services and technology that incorporate advanced signal processing to more accurately extract valuable information from biological signals. Through their technology they are committed to improving the lives of patients and the productivity of clinicians and researchers.

[08/04/2015], Sensium Healthcare Ltd, Oxfordshire, United Kingdom Sensium Healthcare, A global pioneer in wireless monitoring of vital signs. The company focus is on ultra-low power, lightweight, monitoring solutions which improve patient care and safety,shorten hospital stays and reduce healthcare costs.

[07/28/2015], Seoul National University, Gwanak-gu, South Korea, Seoul National University, As Korea leading research university, honoring the ideals of a liberal education aim at teaching students a lifelong love of learning that will form the basis for continuous personal growth. It includes 16 Colleges, 1 Graduate School, 9 Professional Graduate Schools with 16,006 Undergrad Students, 10,559 Graduate Students.

[07/16/2015], Boston Scientific, Marlborough, MA, USA, A leading innovator of medical solutions that improve the health of patients around the world. Products and technologies used to diagnose or treat a wide range of medical conditions, including heart, digestive, pulmonary, vascular, urological, women health and chronic pain conditions. Boston Scientific is dedicated to transforming lives through innovative medical solutions that improve the health of patients around the world.

[09/30/2014], Harvard Medical School-Wyss Institute for Biologically Inspired Engineering, Boston, USA, The Wyss Institute aims to discover the engineering principles that Nature uses to build living things, and harnesses these insights to create biologically inspired materials and devices that will revolutionize healthcare and create a more sustainable world. In medicine, the Institute is developing innovative materials, devices, and disease reprogramming technologies.

[03/12/2014], University Medicine Berlin, Bonn, Germany, The Charite is one of the largest university hospitals in Europe. Here, 3700 doctors and scientists heal, do research and teach at the top international level. More than half of the German Nobel Prize winners in medicine and physiology come from the Charite, among them Emil von Behring, Robert Koch and Paul Ehrlich.

[01/23/2014], BioSign GmbH, Ottenhofen, Germany, Developing innovative measurement and therapy systems for professionals and end-users in the subject area vegetative (autonomic) nervous system. BioSign is responding to the growing medical recognition that disturbances in the autonomic nervous system and disturbances in the interplay of the various organs are involved with the autonomic nervous system.

[11/14/2013], University of Rochester, Computer and Electrical Engineering, Rochester, NY, USA. This department has multiple programs related to energy, to health and medicine, to the connected world, and to music. Specific research programs span a wide range, including medical imaging, image processing, genomics, audio and music signal processing, among others.

[10/31/2013], RIT, Microsystem Engineering, Rochester, USA The multidisciplinary program builds on the fundamentals of traditional engineering and science including the manipulation of electrical, photonic, optical, mechanical, chemical, and biological functionality to process, sense, and interface with the world at a nanometer scale.

[09/10/2013], Medtronic, Inc., Mounds View, USA Medtronic develops and manufactures innovative medical device technology and therapies to treat chronic disease worldwide.

[06/11/2013], RIT, Department of Biomedical Engineering, Rochester, USA The RIT mission is to provide technology-based educational programs for personal and professional development. We rigorously pursue new and emerging career areas. We develop and deliver curricula and advance scholarship relevant to emerging technologies and social conditions. Our community is committed to diversity and student centeredness and is distinguished by our innovative and collaborative spirit.

[05/02/2013], Masonic Medical Research Laboratory, Utica, NY, USA The Masonic Medical Research Laboratory is a not-for-profit institute dedicated to improving the health and quality of life for all. The Laboratory primary mission is to conduct high quality basic and clinical research aimed at generating knowledge and information necessary for development of the medical cures and treatments of tomorrow.

[04/22/2013], Universitat Politecnica de Catalunya (Barcelona-Tech), Barcelona, Spain. The Universitat Politecnica de Catalunya (UPC): BarcelonaTech is a public institution dedicated to higher education and research, specialised in the fields of engineering, architecture and science. With a focus on intellectual rigor, critical thinking, a transversal approach to knowledge, educational innovation and entrepreneurship, the UPC produces competent professionals with the skills they need to tackle present and future challenges.

[03/20/2013], Teschnische Universitat(TU), Dresden, Germany. The TU Dresden is one of eleven German universities that were identified as an Excellence University. TUD has about 36.500 students and almost 5319 employees, 507 professors among them, and, thus, is the largest university in Saxony.

[02/08/2013], Baskir State Pedagogical University (BSPU), Ufa City, Russia M. Akmullah BSPU is a large scientific, educational, cultural and social center of the Republic of Bashkortostan. It includes the Institute of Pedagogics, the Institute of Professional Education and Information Technologies, the Institute of Historical and Legal Education, the Institute of Philological Education and Cross-Cultural Communication and 7 departments with about 12 000 students.

[02/01/2013], Chung-Yuan Christian University, Taiwan, China Chung Yuan Christian University is founded on the spirit of Christian love for the world. With faith, hope, and love, we endeavor to promote higher education for the benefit of the Chinese people, aiming at the pursuit and advancement of genuine knowledge in order to maintain our cultural heritage and, thus, to serve humankind.

[12/11/2012], Cardio-QT Ltd., Glasgow,, United Kingdom Headed by Royal College Accredited Cardiologist and Bioengineer supported by PhD Scientists, Cardio-QT Ltd is an award winning, highly innovative Core Cardiac Analysis Laboratory offering an array of sophisticated validated techniques to solve all analytical research problems.

[10/21/2012], National Polytechnic Institute of Mexico, Mexico City,, Mexico The Institute is the State secular free education institution, guide of public technological education in Mexico. A leader in the generation, application, dissemination and transfer of scientific and technological knowledge.

[09/24/2012], Massachusetts General Hospital, Harvard Medical School , Charlestown, MA,, USA Mass General has long been a leader in successfully bridging innovative science with state-of-the-art clinical medicine. With an annual research budget of nearly $764 million, Mass General conducts the largest hospital-based research program in the United States - a program that spans more than 20 clinical departments and centers across the hospital. This funding drives discoveries and breakthroughs in basic and clinical research, which translate into new and better treatments that transform medical practice and patient care.

[05/24/2012], College of Veterinary Medicine, Cornell University, Ithaca, NY,, USA The mission of the Department of Biomedical Sciences is to educate and inform the veterinary and human biomedical communities through our diverse research and clinical service excellence as well as through our commitment to undergraduate, graduate, and veterinary teaching.

[05/02/2012], The Victor Chang Cardiac Research Institute (VCCRI), Sydney, Australia The VCCRI is committed to excellence in research into heart disease and cardiovascular biology, cardiovascular research training, and facilitating the rapid application of research discoveries to patient care.

[02/09/2012], SAIT, Samsung Advanced Institute of Technology, Gyeonggi,, Korea SAIT provides a full spectrum of support so its researchers can focus on creative research, seek the convergence of heterogeneous technologies and take up new challenges. Meanwhile, SAIT also actively engages in "open innovation" to jointly create future value with other research institutions through collaboration.

[01/26/2012], FDA-CDRH: Center for Devices and Radiological Health, Silver Spring, MD, USA FDA Center for Devices and Radiological Health (CDRH) is responsible for regulating firms who manufacture, repackage, relabel, and/or import medical devices sold in the United States. In addition, CDRH regulates radiation-emitting electronic products (medical and non-medical) such as lasers, x-ray systems, ultrasound equipment, microwave ovens and color televisions.

[01/10/2012], Department of Physiological Nursing, University of California, San Francisco, CA, , USA The Mission of the Department of Physiological Nursing prevention of UCSF is to study the prevention, measurement, and treatment of physiological and biobehavioral responses to health, illness/disease and aging. Psycho-physiological interrelationships and interventions also are studied. Research spans all phases of the health/illness trajectory including people who are healthy, critically ill, living with a chronic illness, and those at the end of life.

[01/03/2012], University of Bologna (HST-ICIR) , Bologna,, Italy The University of Bologna was probably the first University in the western world. Its history is one of great thinkers in science and the humanities, making it an indispensable point of reference in the panorama of European culture. Bologna has thus been called upon to forge relationships with institutions in the most advanced countries to modernise and expand its activity. Among the many challenges which it has met with success, Bologna committed itself to the European dimension which has now led to adoption of the new university system.

Press Center

[09/23/2010]: AstraZeneca joins the THEW to further cardiac safety inThe Medical News: here.

[12/16/2009]: The Director of the THEW interviewed by Technology Review published by the MIT: here.

[11/11/2009]: New Research Center to Focus on Cardiac Safety and Innovation in Pharmaceutical Industry Today: here.

[6/11/2009]: University of of Rochester and FDA Partner for ECG Database, Drug Discovery & Development Magazine. More info here

[5/6/2009] FDA website Existing Partnerships FDAs Public-Private Partnership Program: THEW

[03/28/2009] Public and Private part- nership to help determine Clinical Biomarker Utility in Applied Clinical Trials>here

Guidelines for the LBBB Initiative of the ISCE 2018 meeting

The presence of left bundle branch block (LBBB) is an important predictor of benefit from cardiac resynchronization therapy (CRT), a heart failure device therapy applied in ~75,000 patients per year in the United States. However, approximately one-third of patients diagnosed with LBBB may not benefit from CRT because they do do not have activation consistent with a true LBBB. To address the need for improved LBBB detection, new “strict” ECG criteria for LBBB, that were indeed shown to better predict benefit from CRT, were recently proposed.

The newly proposed “strict” LBBB criteria include: QRS duration ≥140 milliseconds (men) or ≥130 milliseconds (women), QS- or rS-configurations of the QRS complex in leads V1 and V2, and mid-QRS notching or slurring in ≥2 of leads V1, V2, V5, V6, I and aVL(Strauss DG, et al. Am J Cardiol 2011; These new “strict” LBBB criteria are not regularly used and most hospital systems and physicians still use more conventional criteria to diagnose LBBB which could lead to a higher false-positive rate of LBBBs.

This year’s International Society for Computerized Electrocardiology (ISCE) meeting will contain a session on Device Therapies for Heart Failure. One part of the session will focus on diagnosis of LBBB, due to its importance in identifying which patients will benefit from CRT. ISCE and the Telemetric and Holter Initiative ( invite any interested potential attendees (academic, industry, government) to study the “strict” LBBB diagnosis using their existing or novel methods. The data used in this initiative are from the MADIT-CRT trial conducted at University of Rochester (Rochester, NY). The data will be shared in ISHNE format and available for download in December 2017 with agreement from Boston-Scientific Inc.


The objective of the initiative is to give investigators interested in this field of computerized electrocardiography an opportunity to present the outcome of their automatic algorithm for “strict” LBBB diagnosis as well as their potential algorithm improvements for LBBB detection in heart failure patients included in the MADIT-CRT clinical trial. The 12-lead high-resolution ECGs were recorded before CRT implantation using 24-hours Holter recorders (H12+, Mortara Instruments, Milwaukee, WI, USA) with Mason-Likar lead configuration (the Mortara system provides 10 electrodes and records 8-lead signals [I, II, V1-V6] the other 4 leads are calculated). The first 20-minute ECG signals were recorded while the patients were in a supine position. The sampling frequency was 1 kHz and amplitude resolution 3.75 microVolts.

The investigators can download two datasets of 10-second recordings in ISHNE format and will be expected to electronically submit a set of results in a pre-defined comma separated value (CSV) format. These results will then be processed using a standard reporting system developed at the FDA, and the results will be presented during the ISCE session in April 2018. To facilitate participant’s algorithm development and testing, the initiative provided a training dataset (including ECGs and LBBB labels, N= 300 and a validation dataset (ECGs with no LBBB labels, N= 302. The LBBB labels of the validation dataset as well as the scripts used for statistical analysis and report generation will be released on the THEW website after ISCE 2018 for transparency and to facilitate further research. All ECGs provided in the learning and validation sets have been manually adjudicated for “strict” LBBB presence by 2 independent physicians and differences were resolved by consensus in a tie-break with a third reviewer. In detail, the adjudication process was as follows:

1. A median beat was derived from the 10-second ECG. These were constructed using a 10-second window of sinus rhythm beats.

2. The global QRS duration was determined on the median beat across all 12-leads (i.e. butterfly plot). QRS-onset and QRS-offset annotations were manually adjusted where necessary.

3. Visual determination of QS- or rS-configurations in leads V1 and V2 on the median beat in these leads.

4. Visual determination of mid-QRS notching or slurring in ≥2 of leads V1, V2, V5, V6, I and aVL and their starting position relative to the beginning of the global QRS complex (in ms). A slur or notch was required to begin after the first 40 ms and before 50% of the QRS duration and had to end before 2/3rd of the QRS duration.

Of note: For the manual adjudication, if steps 2 and 3 above were found not to meet strict LBBB criteria the ECG was not adjudicated further (i.e. no notches/slurs were annotated even though they may be present).

Of note, the datasets include other forms of left ventricular conduction that are not “strict” LBBB. The initiative will provide labels for whether “strict” LBBB is present or not.

The provided data only includes the ECG signals (10-second strips and medians) and whether the specific subject is male or female. No other subject information form the trial is or will be made available.

Overall the set of data includes: 602 files recorded in the MADIT-CRT clinical trial (~72% men, ~28% women). The dataset includes 10-second 10-electrode 12-lead Mason-Likar ECGs extracted from 20-minutes continuous ECG recorded in supine position.

Investigators participation and requirements:

The registration is free and any organization is invited to participate in this initiative. The only requirement for participation is to register to the initiative through the THEW Registration system provided below. Participation is validated at the time of the upload of the result file to the THEW submission website. The format of the results file is outlined below.

The deadline for submission is March 31, 2018.

One single upload will be permitted. Submission past this deadline will not be accepted.

The results will be presented on 04/26/2018 during the ISCE annual meeting to be held at:

The Chateaux Deer Valley
7815 Royal Street East
Park City, Utah 84060
United States

It is planned to have: 1. a presentation on the research and importance of LBBB in heart failure and cardiac resynchronization therapy, 2. A brief presentation from the best submission(s) from investigators participating in the initiative and 3. a summary presentation of the results.

OF NOTE: If the number of submissions is too large only a selection of the best submissions will be presented during the conference. Selection criteria include quality of results and proposed slide presentation of the results.

Below is a step-by-step description of the registration process for the LBBB challenge. Any questions should be directed to: Dr. Robbert Zusterzeel ( or Dr. Jean-Philippe Couderc (

Step-by-step registration and guidelines for contributing to the ISCE 2018 LBBB Initiative:

Step 1: Register and download the training data

Go to THEW website for registration at: (

Once you have registered to the intiative we will send you a link to download the data. The files include 10-second extractions and median beats in addition to a CSV file with the training set annotations (no annotations in the test set).)

Step 2: Process the ECG files

Apply your ECG algorithm to automatically detect “strict” LBBB from the 12-lead ECGs.

Step 3: Upload your results (see specifics in the table below)

Please upload your CSV file to the THEW submission website. The link to this website will be sent by email after your registration is completed and processed. Your results should be saved in a CSV file to be uploaded using the link you received after registering to the initiative.


**OF NOTE: The specific location of notches/slurs in the individual leads is not required (see table below) but is very much encouraged to maximize the goals and impact of the initiative.

PTID Patient ID


Patient's sex (F=Female, M= Male)
QRS_BEGIN* Annotation for beginning of the Global QRS (ms)
QRS_END* Annotation for end of the Global QRS (ms)
QRS Global QRS duration (ms)
V1_QSRS QS or rS in lead V1 (yes or no)
V2_QSRS QS or rS in lead V2 (yes or no)
I_BEGIN *^ Annotation for beginning of notch/slur in lead I relative to beginning of Global QRS (ms)
I_END *^ Annotation for end of notch/slur in lead I relative to beginning of Global QRS (ms)
AVL_BEGIN *^ Annotation for beginning of notch/slur in lead aVL relative to beginning of Global QRS (ms)
AVL_END *^ Annotation for end of notch/slur in lead aVL relative to beginning of Global QRS (ms)
V1_BEGIN *^ Annotation for beginning of notch/slur in lead V1 relative to beginning of Global QRS (ms)
V1_END *^ Annotation for end of notch/slur in lead V1 relative to beginning of Global QRS (ms)
V2_BEGIN *^ Annotation for beginning of notch/slur in lead V2 relative to beginning of Global QRS (ms)
V2_END *^ Annotation for end of notch/slur in lead V2 relative to beginning of Global QRS (ms)
V5_BEGIN *^ Annotation for beginning of notch/slur in lead V5 relative to beginning of Global QRS (ms)
V5_END *^ Annotation for end of notch/slur in lead V5 relative to beginning of Global QRS (ms)
V6_BEGIN *^ Annotation for beginning of notch/slur in lead V6 relative to beginning of Global QRS (ms)
V6_END *^ Annotation for end of notch/slur in lead V6 relative to beginning of Global QRS (ms)
LBBB LBBB present (yes or no)


* Submission for this item is optional but is very much encouraged ^ If there is more than 1 notch/slur in a single lead, then the timings should be separated by a semi-colon (;)