High-Resolution 12-lead continuous ECG from Patients undergoing Bruce protocol and myocardial perfusion imaging |
|---|
IDENTIFICATION : E-OTH-12-0927-015 |
Study Design: This database includes 927 patients referred for exercise myocardial perfusion single photon emission computed tomography (SPECT) in two medical centers (Assuta Medical Center, and Sheba Medical Center). High resolution 12 lead ECG (HyperQ Stress System, BSP Ltd, Tel Aviv, Israel) was continuously recorded throughout baseline, exercise and recovery phases. ECG acquisition was performed at a rate of 1000 samples/second using 16 bit resolution (measurement sensitivity < 0.15V), with an analog frequency response of 0.05 to 125Hz. Conventional ECG monitoring during the exercise test was either extracted automatically from the high resolution ECG traces or acquired using an additional ECG device (Q-Stress, Quinton Inc, WA), using a second set of 10 electrodes. The patients underwent either stress/rest 99mTc-sestamibi gated SPECT, or stress/ redistribution 201Tl SPECT. Perfusion images were visually scored using a 20-segment model of the left ventricle and a 5-point scale (0=normal tracer uptake, 1=mildly reduced, 2=moderately reduced, 3=severely reduced, 4=no uptake). This analysis was performed by expert interpreters (TS or PC), over-riding automatic segmental scores, obtained by commercial software (QPS, Cedars Sinai Medical Center, Los Angeles, CA). The summed stress score and summed rest score were calculated as the sum of the individual segment scores for the stress and rest images and converted to percent total myocardium (% myocardium) by dividing by 80 (maximal potential score = 4 20). The amount of ischemic myocardium (IM) was calculated as the summed difference score (the difference between summed stress and summed rest scores) divided by 80. Patients were classified as: no ischemia or equivocal (IM<5%), mild ischemia (5%=IM<10%) and moderate/severe ischemia (IM=10%).
Study Population:
Exclusion criteria were cardiac pacemaker, atrial fibrillation at the time of testing and QRS duration = 120 msec. The exercise protocol was as follow: beta blockers and calcium channel blockers were discontinued at least 48 hours before testing. A symptom-limited treadmill exercise test was performed using the Bruce protocol.
ECG Number of Leads: 12 lead standard configuration
ECG Sampling Frequency : 1000Hz
ECG Amplitude Resolution: 0.15 uV
File Naming Convention: Each filename is composed by a unique "ID".
ECG Quality Information: List of ECG files with low quality recording:
| PR01_210404_7 | Very high risk during exercise |
| PR01_0407183_3 | short given ECG |
| 1/ List of ECG files with incomplete data: No adjudication or SPECT remarks available | PR01_220404_3 |
|---|
| PR01_300404_3 |
| PR01_040519_6 |
| PR01_040714_2 |
| PR01_040726_2 |
| PR01_040729_2 |
| PR01_040729_3 |
| 2/ List of ECG files with image problems: low qualitiy signal or unsatisfactory SPECT images |
|---|
| PR01_060104_1 |
| PR01_170204_3 |
| PR01_220204_5 |
| PR01_060803_2 |
| PR01_190404_2 |
| PR01_040504_9 |
| PR01_131103_2 |
| PR01_040817_2 |
| PR01_040818_3 |
Clinical Information:
The list of clinical factors available in this database are described in the tables below. They includes 9 classes of clinical factors.
1/ General information:
| ID |
| date of test |
| age |
| gender |
| height |
| weight |
| referred reason |
| general_remark |
2/ Comorbidity Risk factors (risk_)
| risk_familty (Y/N) |
| risk_Family_Hx |
| risk_lipid (type) |
| risk_smoking (Y/N) |
| risk_prev_smoker (Y/N) |
| risk_obesity (Y/N) |
| risk_hypertension (Y/N) |
| risk_hypertension_treat (Y/N) |
| risk_diabetes (Y/N) |
| risk_diabetes_treat (type) |
| risk_systolic_bp (mmHg) |
3/ CAD therapy (hx_cad)
| hx_cad (Y/N) |
| hx_cad_MI (Y/N) |
| hx_cad_MI_year (yr) |
| hx_cad_cath (Y/N) |
| hx_cad_cath_year (yr) |
| hx_cad_cath_vessel (empty) |
| hx_cad_CABG(Y/N) |
| hx_cad_CABG_year (yr) |
4/ Drug Treatment (medicines_)
| medicines_beta_blockers (Y/N) |
| medicines_beta_blockers_taken_on_test (Y/N) |
| medicines_aspirin (Y/N) |
| medicines_ca_blockers (Y/N) |
| medicines_ace_inhibitors (Y/N) |
| medicines_angiotensin (Y/N) |
| medicines_nitrates (Y/N) |
| medicines_diuretics (Y/N) |
| medicines_anti_arrythmic (Y/N) |
| medicines_lower_lipids (Y/N) |
| medicines_diabetes (Y/N) |
| medicines_other (Y/N) |
| medicines_none (Y/N) |
5/ exercise setup (exercise)
| exercise protocol(Bruce protocol) |
| exercise duration_min (min) |
| exercise duration_sec (sec) |
| exercise stage (level) |
6/ rest blood pressure
| rest_HR (BPM) |
| rest_systolic_BP (mmHg) |
| rest_diastolic_BP (mmHg) |
7/ Peak exercise
| peak_exercise_HR (BPM) |
| peak_excercise_systolic_BP (mmHg) |
| peak_exercise_diaystolic_BP (mmHg) |
| MPHR maximum predicted heart rate (BPM) |
| termination reason (max HR, fatigue, chest pain,shortness of breath SOB, ST changes,leg pain, SVT, dizziness) |
| chest pain (Y/N) |
| exercise_Clinical_result (stages) |
8/ ECG exercise symptoms
| exercise_ECG_result (ischemic, non-ischemic, inconclusive, non diagnostic, borderline ischemic) |
| rest ECG (diagnosis) |
| exercise ECG normal (Y/N) |
| exercise ECG depression (Y/N) |
| exercise ECG elevation (Y/N) |
| exercise max_ST_depression(mm) |
| exercise_dep_Lead_I (Y/N) |
| exercise_dep_Lead_II (Y/N) |
| exercise_dep_Lead_III (Y/N) |
| exercise_dep_AVR (Y/N) |
| exercise_dep_AVL (Y/N) |
| exercise_dep_AVF (Y/N) |
| exercise_dep_V1 (Y/N) |
| exercise_dep_V2 (Y/N) |
| exercise_dep_V3 (Y/N) |
| exercise_dep_V4 (Y/N) |
| exercise_dep_V5 (Y/N) |
| exercise_dep_V6 (Y/N) |
| exercise_ST_depression_slope (direction) |
| exercise remarks |
9/ SPECT factors
| spect isotope (thallium, sestamibi) |
| spect camera (brand) |
| spect technique (SPECT, gated SPECT) |
| spect_stress_segment_1 (binary) |
| spect_stress_segment_2 (binary) |
| spect_stress_segment_3 (binary) |
| spect_stress_segment_4 (binary) |
| spect_stress_segment_5 (binary) |
| spect_stress_segment_6 (binary) |
| spect_stress_segment_7 (binary) |
| spect_stress_segment_8 (binary) |
| spect_stress_segment_9 (binary) |
| spect_stress_segment_10 (binary) |
| spect_stress_segment_11 (binary) |
| spect_stress_segment_12 (binary) |
| spect_stress_segment_13 (binary) |
| spect_stress_segment_14 (binary) |
| spect_stress_segment_15 (binary) |
| spect_stress_segment_16 (binary) |
| spect_stress_segment_17 (binary) |
| spect_stress_segment_18 (binary) |
| spect_stress_segment_19 (binary) |
| spect_stress_segment_20 (binary) |
| spect_rest_segment_1 (binary) |
| spect_rest_segment_2 (binary) |
| spect_rest_segment_3 (binary) |
| spect_rest_segment_4 (binary) |
| spect_rest_segment_5 (binary) |
| spect_rest_segment_6 (binary) |
| spect_rest_segment_7 (binary) |
| spect_rest_segment_8 (binary) |
| spect_rest_segment_9 (binary) |
| spect_rest_segment_10 (binary) |
| spect_rest_segment_11 (binary) |
| spect_rest_segment_12 (binary) |
| spect_rest_segment_13 (binary) |
| spect_rest_segment_14 (binary) |
| spect_rest_segment_15 (binary) |
| spect_rest_segment_16 (binary) |
| spect_rest_segment_17 (binary) |
| spect_rest_segment_18 (binary) |
| spect_rest_segment_19 (binary) |
| spect_rest_segment_20 (binary) |
| spect_SSS (level) |
| spect_SRS (level) |
| spect_SDS (level) |
| spect_ischemia_LAD (level) |
| spect_ischemia_DIAGONAL(level) |
| spect_ischemia_LCA(level) |
| spect_ischemia_RCA(level) |
| spect_ischemia_TOTAL(level) |
| spect_infarction_LAD(level) |
| spect_infarction_DIAGONAL(level) |
| spect_infarction_LCA(level) |
| spect_infarction_RCA(level) |
| spect_infarction_TOTAL(level) |
| spect_LV_TID(level) |
| spect_lung_thallium(level) |
| spect_remarks |
| Spect Summary (ischemic vs. non-ischemic) |