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This new database (E-OTH-03-0802-018) hosts the 20-minute ECGs recorded during the trial designed to determine whether opening an occluded infarcted artery (percutaneous coronary intervention: PCI) 3-28 days after an acute myocardial infarction in high-risk asymptomatic patients reduces the composite endpoint of mortality, recurrent myocardial infarction, and hospitalization for class IV congestive heart failure over a three year follow-up.

The trial was conducted as a randomized study involving 2166 stable patients who had total occlusion of the infarct-related artery 3 to 28 days after myocardial infarction and who met a high-risk criterion (an ejection fraction of <50% or proximal occlusion).

Of these patients, 1082 were assigned to routine PCI and stenting with optimal medical therapy, and 1084 were assigned to optimal medical therapy alone. The trial demonstrated that PCI did not reduce the occurrence of death, reinfarction, or heart failure. Furthermore, there was a trend toward excess reinfarction during 4 years of follow-up in stable patients with occlusion of the infarct-related artery 3 to 28 days after myocardial infarction.

Shared by the New York School of Medicine and SUNY, this new database includes 802 ~20-minute ECG recordings from a subset of 302 patients enrolled in the OAT trial (3.6 Holter recordings per patient in average). The access to this database requires THEW members to submit a short research proposal that will be reviewed by an ad-hoc committee consisting of the principal investigators of the OAT trial and its Holter-related substudy (i.e. Prof. Judith Hochman, MD from the NYU Langone Medical Center and Prof. Eric Rashba from Stony Brooke University of Medicine). In addition to the ECG recordings, this new database includes a large set of clinical information which is described here.

Also, we announce a brand new THEW website redesigned to facilitate access to the most popular pages. These pages include a descriptive list of the THEW databases, a description of the standard ECG file format used in the THEW, and the growing list of publications based on the data shared with private and public organizations world-wide. Finaly, we introduce a library of MATLAB and C++ codes freely available to download from the website. It contains procedures to access the data from the THEW SFTP within MATLAB to directly read and decode the ECG file format and annotation file format from the MATLAB platform.

The THEW LQTS database contains 480 Holter recordings from genotyped patients with the congenital long QT syndrome (LQTS). The database has been recently updated with new annotation files that are full manual adjudication of the 24-hour recordings by expert ECG technicians. This database has been one of the most distributed datasets of the THEW repository.

It contains the patient genetic information and information about patients' cardiac events before or after the time of the Holter recording. More information about the database is provided in the database webpage: E-HOL-03-0480-013

THEW NEW WEBSITE click to visit the website.

by D. Guldenring, School of Computing and Mathematics, University of Ulster, Belfast, United Kingdom