New Members

07/03/2024, Lucerne University of Applied Sciences and Arts, Luzern, Switzerland

07/03/2024, Hassan first University , Settat, Morocco

07/03/2024, Hochschule Luzern T&A, Horw, Switzerland

07/03/2024, Università Politecnica delle Marche, Ancona AN, Italy

01/29/2024, National Taiwan University of Science and Technology, Taipei City, Taiwan

10/17/2023, University of Toronto , Mississauga Ontario , Canada

7/27/2023, University Toledo, Toledo, USA

4/5/2023, ZheJiang Normal University, Zhejiang Province, China

04/11/2023, University of Nebraska at Omaha, Omaha, USA

01/17/2023, University of Limerick, Limerick, Ireland

09/13/2023, Universidad del Rosario, Bogonta , Colombia

08/22/2023, BioCardia, Sunny Val, USA Bringing personalized medicine to cell therapy for heart disease

06/27/2022, Punjabi University Patiala, Punjab, India

06/01/2022, Kestra Medical Technologies, Inc., Kirkland, USA Kestra Medical Technologies is a wearable medical device and digital healthcare company that protects patients with diagnostic and therapeutic technologies that are intuitive, intelligent, and mobile.

06/07/2021, University of Valladolid, Valladolid, Spain

04/30/2021, ETH Zurich, Zürich, Switzerland

04/30/2021, University Carlos III Madrid Lopez, Madrid, Spain

04/30/2021, Shahid Rajaee Teacher Training University, Tehran Province, Iran

01/12/2021, The National Academy of Sciences of Ukraine, Kyiv, Ukraine

01/12/2021, Universidad Rey Juan Carlos, Madrid, Spain

01/12/2021, Universidad iberoamericana, Mexico City, MEXICO

01/12/2021, Clinical Technology , Brecksville, USA

06/05/2020, Universitat Pompeu Fabra, Barcelona, Spain

06/05/2020, SUNY Upstate Medical University, Syracuse, USA

05/28/2020, University of Kent, Canterbury, United Kingdom

05/28/2020, The University of AIZU, Fukushima, Japan

05/28/2020, National Taiwan University, Taipei City, Taiwan

02/28/2020, Indian Institute of Space & Science & Tech, Kerala, India To be a world class educational and research institution contributing significantly to the Space endeavours

02/20/2020, Monash University, Melbourne, Australia Monash University is one of Australia’s leading universities and ranks among the world’s top 100. We help change lives through research and education.

12/24/2019, Universidad Politécnica de Madrid, Madrid, SPAIN

11/11/2019, University of Verona, Verona, ITALY

11/11/2019, University of Pittsburgh, Pittsburgh, USA The University of Pittsburgh is a state-related research university, founded as the Pittsburgh Academy in 1787. Pitt is a member of the Association of American Universities (AAU), which comprises 62 preeminent doctorate-granting research institutions in North America.

11/11/2019, Tianjin University of Technology, Tianjin , CHINA Tianjin University is the oldest institution of higher education in the modern history of China. Founded in 1895 as Peiyang University, Tianjin University’s 123-year history is the epitome of the progress of modern Chinese higher education, embodying the Chinese people’s indomitability through challenging times.

11/01/2019, Parsons Government Service, HOUSTON, USA Founded in 1944, Parsons Corporation --- a digitally enabled solutions provider --- is focused on the defense, intelligence, and critical infrastructure markets.

10/31/2019, University of Liverpool, Liverpool, UK

10/31/2019, Air University Islamabad, Islamabad, Pakistan The mission of Air University is to achieve excellence in teaching and research for producing graduates with sound professional knowledge, integrity of character, a keen sense of social responsibility and a passion for lifelong learning. The University shall stand committed to creating an environment conducive for attracting the best students, faculty and supporting staff for contributing to the development of a prosperous, peaceful and enlightened society.

05/15/2019, University of Wisconsin, Madison, USA For 168 years, this campus has been a catalyst for the extraordinary. As a public land-grant university and prolific research institution, our students, staff, and faculty members partake in a world-class education and solve real-world problems

05/15/2019, Utrecht University, Utrecht, NETHERLANDS

05/15/2019, University of Michigan, Ann Arbor, USA

05/15/2019, University of California Los Angeles, os Angeles, USA

05/15/2019, University of California Irvine, Irvine, USA Founded in 1965, UCI is the youngest member of the prestigious Association of American Universities. The campus has produced three Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UCI has more than 36,000 students and offers 222 degree programs.

05/15/2019, Technion , Haifa, ISRAEL A science and technology research university, among the world’s top ten,

05/15/2019, Tampere University of Technology, Tampere, FINLAND Tampere University is one of the most multidisciplinary universities in Finland. Almost all internationally recognised fields of study are represented at our university.

05/15/2019, Shenzhen Institute of Advanced Technology, Shenzhen, CHINA

05/15/2019, Shanghai Jiao Tong University, Shanghai, CHINA

05/15/2019, Saint Petersburg Electrotechnical University, Sankt-Peterburg, RUSSIA Saint Petersburg Electrotechnical University "LETI" is one of the world's largest education centers specializing in radio engineering, electrical engineering, electronics and computer science.

05/15/2019, Pontifical Xavierian University, Bogotá, Colombia

05/15/2019, University of Sfax , Sfax, TUNISIA

05/15/2019, King Saud University, Riyadh , SAUDIA ARABIA

05/15/2019, Khalifa University, Abu Dhabi, UNITED ARAB EMIRATES The newly-established Khalifa University of Science and Technology (KU) combines the Masdar Institute of Science and Technology (MI), the Khalifa University of Science, Technology and Research (KUSTAR) and the Petroleum Institute (PI) into one world-class, research-intensive institution, seamlessly integrating research and education to produce world leaders and critical thinkers in applied science and engineering.

05/15/2019, Argentine Institute of Mathematics, Buenos Aires , ARGENTINA

05/15/2019, INESC TEC, Porto, PORTUGAL INESC TEC is a private non-profit research institution, dedicated to scientific research and technological development, technology transfer, advanced consulting and training, and pre-incubation of new technology-based companies.

05/15/2019, Fraunhofer HHI, Berlin, GERMANY Innovations for the digital society of the future are the focus of research and development work at the Fraunhofer Heinrich Hertz Institute HHI. In this area, Fraunhofer HHI is a world leader in the development of mobile and optical communication networks and systems, fiber optical sensor systems as well as the processing and coding of video signals.

05/15/2019, Heart Input Output, Inc., Pittsburgh, USA

05/15/2019, Harrisburg University, Harrisburg, USA

05/15/2019, Warsaw University of Technology, Warsaw, POLAND

05/15/2019, Carlos III University of Madrid , Madrid, SPAIN UC3M´s mission is to contribute to the improvement of society through teaching of the highest quality and cutting-edge research in line with stringent international guidelines. The University aspires to excellence in all its activities, with the aim of becoming one of the top universities in Europe.

05/15/2019, Beth Israel Deaconess Medical Center, Boston, USA BIDMC is part of Beth Israel Lahey Health, a new health care system that brings together academic medical centers and teaching hospitals, community and specialty hospitals, more than 4,000 physicians and 35,000 employees in a shared mission to expand access to great care and advance the science and practice of medicine through groundbreaking research and education.

[01/24/2018], Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary The BRC is an outstanding institution of the internationally acknowledged Hungarian biological research. The Biological Research Centre was founded in 1971. The 4 institutes of BRC - the Institutes of Biophysics, Biochemistry, Genetics and Plant Biology - employ about 260 scientists whose work is hall-marked by highly appreciated international scientific publications and patents. The research topics include several fields of molecular and cell biology from the industrial utilization of bacteria through controlled improvement of cultivated plants to the problems of human health and environmental protection. BRC is mainly a scientific basic research centre, but scientists of BRC play an initiative role in the foundation and promotion of biotechnological companies, as well as in educational duties.

[01/02/2018], Universidade Federal do Maranhão, São Luís - MA, Brazil Founded in 1966, Universidade Federal do Maranhão (Federal University of Maranhão) is a non-profit public higher education institution located in the medium-sized city of São Luis (population range of 500,000-1,000,000 inhabitants), Maranhao. Officially accredited and/or recognized by the Ministério da Educação, Brazil (Ministry of Education, Brazil), Universidade Federal do Maranhão (UFMA) is a coeducational higher education institution. Universidade Federal do Maranhão (UFMA) offers courses and programs leading to officially recognized higher education degrees such as bachelor degrees in several areas of study.

[03/12/2018], University of Vigo, Viigo, Spain The University of Vigo is a modern and innovative institution, which offers more than 50 degree courses on three different campuses: a) the Vigo campus – which includes both the Lagoas Marcosende campus (15 km from the city centre) and the historical campus at Torrecedeira, b) the Ourense campus, and c) the Pontevedra campus. More than 24,000 students are registered at the three campuses, and 1,600 lecturers teach undergraduate and postgraduate programs at the University of Vigo. Our institution offers degrees in all knowledge areas, especially in the scientific-technological field. Some of the degrees are unique within the Galician university system and not very common in the rest of the Spanish universities: Fine Arts on the Pontevedra Campus, Mining and Telecommunication Engineering on the Vigo campus, and Tourism on the Ourense campus.

[01/24/2018], Stanford Medicine, Stanford, USA A leader in the biomedical revolution, Stanford Medicine has a long tradition of leadership in pioneering research, creative teaching protocols and effective clinical therapies. Our close proximity to the resources of the university — including the Schools of Business, Law, Humanities and Sciences, and Engineering, our seamless relationship with our affiliated adult and children’s hospitals, and our ongoing associations with the entrepreneurial endeavors of Silicon Valley, make us uniquely positioned to accelerate the pace at which new knowledge is translated into tangible health benefits.

[01/24/2018], The Austrian Research Institute for Artificial Intelligence, Vienna, Austria The Austrian Research Institute for Artificial Intelligence (OFAI) is one of Europe's leading non-profit contract research institutions. Services offered range from consultancy, basic and applied research on a contractual base, to working as partner or prime contractor in scientific projects on a national or European level, with a twenty year experience in a diversity of domains, from economic, engineering, administrative to social and cultural tasks.

[10/25/2017], University of Tennessee Health Science Center, Memphis, USA As the flagship statewide, public, academic health system, the mission of the University of Tennessee Health Science Center is to bring the benefits of the health sciences to the achievement and maintenance of human health, with a focus on the citizens of Tennessee and the region, by pursuing an integrated program of education, research, clinical care and public service. Employing more than 6,000 people on its faculty, staff and not-for-profit corporation faculty practice groups, UTHSC contributes more than $2.7 billion to the economy of Tennessee.

[10/24/2017], Dankook University, Yongin-si,, South Korea Dankook University cherishes truth and service as its guiding principles. It is our belief that the purpose of research and study lies beyond simply acquiring tools for sustenance – the ultimate purpose of higher learning is the enrichment of human knowledge and culture. Principally, scholars are obligated to return such knowledge to society and contribute to historical advancement. They must seek to develop sharp, critical minds and a righteous moral character; by doing so and voluntarily participating in the betterment of society as a whole, one embodies the path Dankook wishes to set forth. It has been the unwavering devotion towards realizing such duties of higher education and patriotism that has led to Dankook University’s existence in its current form

[09/28/2017], Chinese PLA General Hospital, Beijing, China The Chinese People’s Liberation Army (PLA) General Hospital is a large, modern, comprehensive teaching hospital providing high quality health care and opportunities for postgraduate medical education and scientific research. The hospital was founded in 1953, and is situated on the western part of the 4th Beijing Ring Road. The hospital has 165 clinical medical departments, which each year accept 49,000 outpatients and emergency patients while performing nearly 90,000 surgery cases. The medical- health care center is noted for providing high-end preventive care services.

[07/20/2017], University of Central Florida, Orlando, USA The Advanced Research Computing Center (ARCC) at the University of Central Florida houses high performance computing resources for use in research by faculty across campus. Research supported by the ARCC covers a variety of different disciplines, including Engineering, Modeling and Simulation, Optics, Nanoscience, and many others. The ARCC staff also pursues research in machine learning and visualization, as well as information technology. Currently, the center houses a high performance computing system known as Stokes, which is used to help support and drive research within the university.

[05/02/2017], Shandong University, , China Founded in 1901, Shandong University, based in Jinan, China, is the nation’s largest public university. It has prepared over 400,000 individuals in a variety of specialties, and has been making significant contributions to the country’s economic and social development. The growth of the university has allowed it to rise to the forefront of many fields in China. They continually develop new disciplines such as crystal materials, cardiovascular functional recovery, and new drug manufacturing to stay on the cutting edge of scientific research. Many of these newly formed disciplines have quickly risen to the first-class level within the country, and some are even know abroad.

[02/17/2017], University of Porto, Praça de Gomes Teixeira, Portugal The University of Porto, founded in 1911, is a leading scientific and research institution located in Portugal. The university is internationally recognized for the quality of research it produces, and is consistently ranked among the 150 best European universities. It is an important driver of economic, social, and scientific development within Portugal, and strives to be a strong partner of the business community. By combining quality teaching with a focus on market needs, the university strives to actively participate in, and encourage, the progress of communities in which it operates.

[05/24/2016], Marche Polytech University, Ancona, Italy The Department of Life and Environmental Sciences was established in 2011 by merging a number of laboratories involved in a wide spectrum of fundamental and applied research topics. The department is a center of excellence of the Università Politecnica delle Marche and includes more than 100 scientists and technicians that conduct research in areas such as analytical and organic chemistry, biophysics, cellular and molecular biology, biochemistry and genetics, microbiology and biotechnology, viral, prokaryotic, fungal, algal, plant and animal systematics, physiology and reproduction, marine biology, ecology, eco-toxicology, oceanography, Earth sciences, risk reduction and civil protection.

[05/12/2016], University of Buenos Aires, Buenos Aires, Argentina Buenos Aires University consists of thirteen colleges/schools, dozens of research institutes, and two secondary schools, offering more than 100 undergraduate majors. There is a teaching staff of 30,000 teachers, and approximately 300,000 students; 30% of scientific research in Argentina takes place at UBA. Standard undergraduate studies last approximately 5 years. Buenos Aires University offers several graduate programmers, masters, PhDs, and specialization courses as well.

[05/12/2016], Queen's University, Kingston, Canada The mission of Queen's University has been articulated in a number of different forms and formats over the past decade. In all of the presentations, the key elements have remained constant: The University will build on the strength that is Queen's - students, faculty, staff and alumni - to be among the best of internationally known universities in Canada, recognized for: •the exceptional quality of undergraduate and graduate students and programs in the arts, sciences and professions; •the intellectual power and value of research and scholarship by faculty members and students; •the exemplary service of the University and that of its graduates to the community and the nation and the community of nations.

[04/28/2016], University of Leuven, Leuven, Belgium KU Leuven is a research-intensive, internationally oriented university that carries out both fundamental and applied research. It is strongly inter- and multidisciplinary in focus and strives for international excellence. To this end, KU Leuven works together actively with its research partners at home and abroad.KU Leuven encourages personal initiative and critical reflection in a culture of idea exchange, cooperation, solidarity and academic freedom.

[03/07/2016], Mayo Clinic, Rochester, USA Mayo Clinic is the first and largest integrated nonprofit medical group practice in the world, employing more than 3,800 physicians and scientists, as well as 50,900 allied health staff. Based out of Rochester, MN, the Mayo Clinic’s mission is “to inspire hope and contribute to health and well-being by providing the best care to every patient through integrated clinical practice, education, and research.” The practice specializes in treating difficult cases through tertiary care, and spends over $500 million a year on research. It was also recognized as one of the best hospitals in the U.S. for 2015-2016 by U.S. News & World Report.

[03/02/2016], Czech Technical University, Prague, Czech Republic The Czech Technical University in Prague (CTU) is an internationally recognized higher education and research institution with more than 300 years of tradition and excellence. CTU is a leading technical research university with a large focus on cutting edge science and engineering, paired with a high-quality technical education. With 8 departments each focused on an engineering specialty, the university educates modern specialists, scientists, and managers who are dynamic, flexible, and able to rapidly adapt to the requirements of the market.

[02/10/2016], CERB, Baugy, France Located in Baugy, France, CERB was founded in 1973 and has developed into a leading international contract research organization (CRO) in the fields of pre-clinical pharmacology and toxicology. Taking on the challenges of modern drug development, CERB has created a distinctive image as a leading major service provider to the pharmaceutical industry in the context of innovative bio-medical research. CERB takes advantage of its sophisticated synergy between pharmacology and toxicology resources to provide complete pre-phase I packages for new molecules in an economic and timely manner

[01/07/2016], Goergen Institute for Data Science (GIDS), Rochester, USA The GIDS supports faculty research, particularly collaborative public-private research partnerships spanning several domains, such as developing health care breakthroughs, improving our knowledge of how the brain works, and creating tools and systems to efficiently use data. The GIDS is working to build strategic alliances and business partnerships among the academic, government, and business communities, leveraging University of Rochester expertise.

[10/06/2015], Dresden University of Technology, Dresden, Germany Dresden University of Technology is one of eleven German universities that were identified as an “excellent university", and includes over 37,000 students with 14 institutions offering a wide range of academic programs. The Institute of Biomedical Engineering focuses on the early detection, diagnosis, and treatment of life-threatening cardiovascular disease. With a strong focus on research.

[10/06/2015], Biomedical Systems, Maryland Heights, USA Biomedical Systems has set the health care industry standard by providing innovative approaches to non-invasive diagnostic services, clinical trials, and products. They provide their clients with the ability to increase cost efficiencies and bring studies to database lock on an advanced timeline by combining over 20 modalities in one study. Biomedical Systems' pioneering spirit is based on a strong history as a privately held company that focuses on clients and people.

[09/15/2015], VivaQuant LLC, Shoreview, USA VivaQuant provides products, services and technology that incorporate advanced signal processing to more accurately extract valuable information from biological signals. Through their technology they are committed to improving the lives of patients and the productivity of clinicians and researchers.

[08/04/2015], Sensium Healthcare Ltd, Abingdon, UK Sensium Healthcare, A global pioneer in wireless monitoring of vital signs. The company focus is on ultra-low power, lightweight, monitoring solutions which improve patient care and safety,shorten hospital stays and reduce healthcare costs.

[07/28/2015], Seoul National University, , South Korea, Seoul National University, As Korea leading research university, honoring the ideals of a liberal education aim at teaching students a lifelong love of learning that will form the basis for continuous personal growth. It includes 16 Colleges, 1 Graduate School, 9 Professional Graduate Schools with 16,006 Undergrad Students, 10,559 Graduate Students.

[07/16/2015], Boston Scientific, Marlborough, MA, USA A leading innovator of medical solutions that improve the health of patients around the world. Products and technologies used to diagnose or treat a wide range of medical conditions, including heart, digestive, pulmonary, vascular, urological, women health and chronic pain conditions. Boston Scientific is dedicated to transforming lives through innovative medical solutions that improve the health of patients around the world.

[09/30/2014], Harvard Medical School-Wyss Institute for Biologically Inspired Engineering, Boston, USA The Wyss Institute aims to discover the engineering principles that Nature uses to build living things, and harnesses these insights to create biologically inspired materials and devices that will revolutionize healthcare and create a more sustainable world. In medicine, the Institute is developing innovative materials, devices, and disease reprogramming technologies.

[03/12/2014], University Medicine Berlin, Berlin, Germany The Charite is one of the largest university hospitals in Europe. Here, 3700 doctors and scientists heal, do research and teach at the top international level. More than half of the German Nobel Prize winners in medicine and physiology come from the Charite, among them Emil von Behring, Robert Koch and Paul Ehrlich.

[01/23/2014], BioSign GmbH, Ottenhofen, Germany Developing innovative measurement and therapy systems for professionals and end-users in the subject area vegetative (autonomic) nervous system. BioSign is responding to the growing medical recognition that disturbances in the autonomic nervous system and disturbances in the interplay of the various organs are involved with the autonomic nervous system.

[11/14/2013], University of Rochester, Computer and Electrical Engineering, Rochester, USA This department has multiple programs related to energy, to health and medicine, to the connected world, and to music. Specific research programs span a wide range, including medical imaging, image processing, genomics, audio and music signal processing, among others.

[10/31/2013], RIT, Microsystem Engineering, Rochester, USA The multidisciplinary program builds on the fundamentals of traditional engineering and science including the manipulation of electrical, photonic, optical, mechanical, chemical, and biological functionality to process, sense, and interface with the world at a nanometer scale.

[09/10/2013], Medtronic, Inc., Medtronic , USA Medtronic develops and manufactures innovative medical device technology and therapies to treat chronic disease worldwide.

[06/11/2013], RIT, Department of Biomedical Engineering, Rochester, USA The RIT mission is to provide technology-based educational programs for personal and professional development. We rigorously pursue new and emerging career areas. We develop and deliver curricula and advance scholarship relevant to emerging technologies and social conditions. Our community is committed to diversity and student centeredness and is distinguished by our innovative and collaborative spirit.

[05/02/2013], Masonic Medical Research Laboratory, Utica, USA The Masonic Medical Research Laboratory is a not-for-profit institute dedicated to improving the health and quality of life for all. The Laboratory primary mission is to conduct high quality basic and clinical research aimed at generating knowledge and information necessary for development of the medical cures and treatments of tomorrow.

[04/22/2013], Universitat Politecnica de Catalunya (Barcelona-Tech), Barcelona, Spain. The Universitat Politecnica de Catalunya (UPC): BarcelonaTech is a public institution dedicated to higher education and research, specialised in the fields of engineering, architecture and science. With a focus on intellectual rigor, critical thinking, a transversal approach to knowledge, educational innovation and entrepreneurship, the UPC produces competent professionals with the skills they need to tackle present and future challenges.

[03/20/2013], Teschnische Universitat(TU), Berlin, Germany The TU Dresden is one of eleven German universities that were identified as an Excellence University. TUD has about 36.500 students and almost 5319 employees, 507 professors among them, and, thus, is the largest university in Saxony.

[02/08/2013], Baskir State Pedagogical University (BSPU), Uta, Russia M. Akmullah BSPU is a large scientific, educational, cultural and social center of the Republic of Bashkortostan. It includes the Institute of Pedagogics, the Institute of Professional Education and Information Technologies, the Institute of Historical and Legal Education, the Institute of Philological Education and Cross-Cultural Communication and 7 departments with about 12 000 students.

[02/01/2013], Chung-Yuan Christian University, Taiwan, China Chung Yuan Christian University is founded on the spirit of Christian love for the world. With faith, hope, and love, we endeavor to promote higher education for the benefit of the Chinese people, aiming at the pursuit and advancement of genuine knowledge in order to maintain our cultural heritage and, thus, to serve humankind.

[12/11/2012], Cardio-QT Ltd., Glasgow, UK Headed by Royal College Accredited Cardiologist and Bioengineer supported by PhD Scientists, Cardio-QT Ltd is an award winning, highly innovative Core Cardiac Analysis Laboratory offering an array of sophisticated validated techniques to solve all analytical research problems.

[10/21/2012], National Polytechnic Institute of Mexico, Santiago de Querétaro, Mexico The Institute is the State secular free education institution, guide of public technological education in Mexico. A leader in the generation, application, dissemination and transfer of scientific and technological knowledge.

[09/24/2012], Massachusetts General Hospital, Harvard Medical School, Boston, USA Mass General has long been a leader in successfully bridging innovative science with state-of-the-art clinical medicine. With an annual research budget of nearly $764 million, Mass General conducts the largest hospital-based research program in the United States - a program that spans more than 20 clinical departments and centers across the hospital. This funding drives discoveries and breakthroughs in basic and clinical research, which translate into new and better treatments that transform medical practice and patient care.

[05/24/2012], College of Veterinary Medicine, Cornell University, Ithaca, USA The mission of the Department of Biomedical Sciences is to educate and inform the veterinary and human biomedical communities through our diverse research and clinical service excellence as well as through our commitment to undergraduate, graduate, and veterinary teaching.

[05/02/2012], The Victor Chang Cardiac Research Institute (VCCRI), Darlinghurst NSW 2010, Australia The VCCRI is committed to excellence in research into heart disease and cardiovascular biology, cardiovascular research training, and facilitating the rapid application of research discoveries to patient care.

[02/09/2012], SAIT, Samsung Advanced Institute of Technology, Gyeonggi-do, Korea SAIT provides a full spectrum of support so its researchers can focus on creative research, seek the convergence of heterogeneous technologies and take up new challenges. Meanwhile, SAIT also actively engages in "open innovation" to jointly create future value with other research institutions through collaboration.

[01/26/2012], FDA-CDRH: Center for Devices and Radiological Health, Silver Spring, USA FDA Center for Devices and Radiological Health (CDRH) is responsible for regulating firms who manufacture, repackage, relabel, and/or import medical devices sold in the United States. In addition, CDRH regulates radiation-emitting electronic products (medical and non-medical) such as lasers, x-ray systems, ultrasound equipment, microwave ovens and color televisions.

[01/10/2012], Department of Physiological Nursing, University of California, San Francisco, USA The Mission of the Department of Physiological Nursing prevention of UCSF is to study the prevention, measurement, and treatment of physiological and biobehavioral responses to health, illness/disease and aging. Psycho-physiological interrelationships and interventions also are studied. Research spans all phases of the health/illness trajectory including people who are healthy, critically ill, living with a chronic illness, and those at the end of life.

[01/03/2012], University of Bologna (HST-ICIR), Bologna BO, Italy The University of Bologna was probably the first University in the western world. Its history is one of great thinkers in science and the humanities, making it an indispensable point of reference in the panorama of European culture. Bologna has thus been called upon to forge relationships with institutions in the most advanced countries to modernise and expand its activity. Among the many challenges which it has met with success, Bologna committed itself to the European dimension which has now led to adoption of the new university system.

PRESS CENTER

[09/23/2010]: AstraZeneca joins the THEW to further cardiac safety inThe Medical News: here .

[12/16/2009]: The Director of the THEW interviewed by Technology Review published by the MIT: here .

[11/11/2009]: New Research Center to Focus on Cardiac Safety and Innovation in Pharmaceutical Industry Today: here .

[6/11/2009]: University of of Rochester and FDA Partner for ECG Database, Drug Discovery & Development Magazine. More info here

[5/6/2009] FDA website Existing Partnerships FDAs Public-Private Partnership Program: THEW

[03/28/2009] Public and Private part- nership to help determine Clinical Biomarker Utility in Applied Clinical Trials online.com. >here

Newsletter Issue 8, May 2010

Thorough Holter QT studies, LQTS database and NHLBI Cooperation

Editorial by JP Couderc, PhD

This past month we have started a cooperative agreement with the National Heart Lung and Blood Institute (NHLBI). This agreement is a mechanism for our initiative to involve substantial Federal scientific and programmatic support from the NHLBI. The first step in this support is the joining of two scientific staffs within our steering committee to help us guide and coordinate our project activities (see article below). Interestingly, ECG-related research has been strong in the history of the NIH. A personal review of current NIH-funded activities related to ECG has revealed that this reasearch arena is very active. Indeed, the average number of NIH awards related to the development of ECG technologies or relying on ECG information awarded each year between 2000 and 2009 was 153 (based on the Research Portfolio Online Reporting tool (RePORt) from the NIH). More interestingly, there is a trend toward an increasing number of this type of award (see figure below).

report

Left figure: number of NIH awards supported each year and related to development of ECG technologies. Note: this does not include the NIH awards that did not specifically focus on ECGs but could have included basic ECG metrics.

One hundred seventy NIH proposals were awarded in the year 2000. In 2003, fewer than 100 awards were granted representing the smallest number of NIH-funded research projects for this current decade.

The largest number of awards during these past 9 years was released last year (2009) and this number may be primiraly driven by the The American Recovery and Reinvestment Act passed on February 17, 2009. Yet, the graph reveals a clear continuous growth in numbers of awards between 2003 and 2008, with a three fold increase from 83 to 252 projects granted by the NIH in 2008. These numbers confirm the very active research currently implemented either for developing ECG-related technologies or relying on ECG information. The rational for the growing interest in ECG technologies is driven by many factors and amongst the reviewed awards one can note research related to cost-effective cardiac markers, the interest for concepts related to personal cardiac safety and monitoring technologies (ambulatory, home-device, etc.).

Related to the activity of our Center during these past couple of months, we received another set of very interesting Holter recordings from patients with the congenital long QT syndrome. Dr. Fabrice Extramania et al. describes below this population and their effort to gather Holter ECG from genotyped LQTS patients during the past 25 years. This data has been received by our groupand it is available in the warehouse for download.

Publications based on THEW data will soon be available. Numerous abstracts based on the data from the THEW were submitted to the Computing in Cardiology meeting held in Belfast this September. The organizers agreed on planning a THEW session during which the most interesting work done with the THEW data will be presented.

From the regulatory side, continuous QT measured from Holter recordings are going to be reviewed at the FDA in the context of Thorough QT studies involving compounds with pronounced effects on the autonomic nervous system. The CDER released information about a CPI (Critical Path Initiative) fellowship award for a two-year project for the development of review processes of three method : beat-to-beat QT, individual heart-rate correction for QTc and RR bin method. The THEW provides the offcial release of this fellowship.

To conclude, growth is a clear trend for this first half of the year 2010 with more data coming in, additional comittment from federal Agency, release of publications from the THEW scientific network and exciting developments at the FDA related to Holter technologies.

nih Two new members join the THEW Steering Committee: Dr. D. Lathrop and Dr. R. Boineau from the National Heart, Lung and Blood Institute

Dr. David Lathrop and Dr. Robin Boineau have officially joined the Steering Committee of the Telemetric and Holter ECG Warehouse (THEW). Dr. Lathrop is Deputy Chief of the Heart Failure & Arrhythmia Branch of the Division of Cardiovascular Sciences at the National Heart, Lung, and Blood Institute and  Dr. Robin Boineau is Medical Officer at the Cardiology department at the NHLBI.

Dr. Boineau commented on this new cooperation: "David Lathrop and I look forward to joining the THEW as it evolves into the Center for Quantitative Electrocardiography and Cardiac Safety (CES).  We look forward to working with Jean-Philippe Couderc and his colleagues in Rochester, our FDA colleagues, and others as the CES becomes a resource for investigators designing and validating analytic methods in quatitative electrocardiography and cardiac safety."

The THEW team welcomes Drs. Boibeau and Lathrop to the THEW Initiative; we are looking forward to their input into the strategic developments of the project in collaboration with other members from  the FDA and from the University of Rochester.

THEW new database: 24-hour Holter recordings from genotyped patients with the congential long QT syndrome by Fabrice Extramiana, MD, PhD et al.

Torsades de pointes have been initially described in our institution in the sixties and ever since the interest for QT prolongation-related arrhythmias has been very important in our department.
In the mid eighties, Philippe Coumel initiated the systematic recording of Holter ECGs in patients with a prolonged ventricular repolarization.
This Holter database has been nurtured by Isabelle Denjoy, and after discovery of the underlying genetic basis of the syndrome phenotypic ECG data accumulated over 25 years have been linked with the results of genetic data obtained in LQTS patients (N=480).
This primary care-oriented database contains clinical data (demographics, symptomatic status, and beta-blocker treatment at the time of recording) of genotyped LQTS patients who have had one or repeated Holter ECG recording(s).
Over the last 2 decades, recordings have been obtained with different technologies but mainly with the different versions of the ELA Medical software. Data were initially analog recordings that have been subsequently digitized, and more recently recordings are digital but with different formats.

Thanks to the THEW initiative, all recordings have been reformatted into the ISHNE format. We are proud to share our unique Holter database with the scientific community via the THEW initiative. We are confident that allowing other research groups to use our data will speed up the quest for a better understanding of LQTS and hopefully shorten the time to improved risk stratification and treatment strategies.

Fabrice Extramiana, MD, PhD
Pierre Maison-Blanche, MD
Isabelle Denjoy, MD
Antoine Leenhardt, MD

Lariboisière Hospital arrhythmia unit, Paris 7 University, France

FDA Holter analysis in Thorough QT studies: FDA will develop internal review process through a Critical Path Initiative Research Fellowship

Delays in cardiac repolarization (QT/QTc prolongation) are associated with lethal arrhythmias. Evaluation of the QT/QTc prolonging effects of new compounds has been challenging for drugs with pronounced effects on the autonomic nervous system, which can have secondary effects on cardiac repolarization. To identify drug-induced QT/QTc prolongation while adjusting for drug-induced changes in autonomic tone, scientists and experts have proposed analytic strategies relying on continuous Holter monitor recordings.  These methods include: 1) the evaluation of individual QT/RR coupling (QTci); 2) the definition of a normal 24-hour range of QT/RR couplets (QT beat-to-beat), and 3) the design of rate-related referential QT benchmark (RR bin method). These three approaches are considered to be improved analytic strategies to evaluate the effects of a new compound on the QT/QTc interval in situations where the drug also changes the autonomic regulation of the heart. More importantly, these methods can be applied to data recorded in thorough QT studies (TQT studies, adhering to ICH E14 recommendations) if they were designed to use data from continuous 24-hour ECG recordings.

These methods require the analysis of long-term multi-lead continuous recordings, each including on the order of 100,000 cardiac beats on which these measurements are made. The current capacity of the FDA to receive, process, and evaluate this information is insufficient, and the primary objective of the proposed work is to develop these capacities inside the Center for Drug Evaluation and Research (CDER).

The project proposes a two-year research fellowship position at the FDA Campus in Silver Spring, Maryland, for the development of internal quality evaluation, analysis, and collation tools for Holter data submitted to the FDA by pharmaceutical companies. The proposed project would benefit from an individual already familiar with the ECG methods described above, as well as expertise in quantitative electrocardiography. Candidates are invited to participate in the THEW training class (RES950) at University of Rochester Medical Center prior to joining the CDER/FDA.

Official FDA announcement available here in pdf format

cinc THEW Scientific Session planned in the Computing in Cardiology Meeting, Belfast (UK), September 2010.

We are glad to announce that several databases from the THEW have been used for research activities, and the preliminary publications will be soon released during the next Computing in Cardiology (CinC) meeting. CinC ( www.cinc.org ) is an International Scientific Conference that has been held annually since 1974, it provides a forum for scientists and professionals from the fields of medicine, physics, engineering and computer science to discuss their current research in topics pertaining to computing in clinical cardiology and cardiovascular physiology. Eight abstracts were submitted to the Annual Computing in Cardiology (formerly Computers in Cardiology) meeting from various academic and private partners of the THEW. The CinC organizers agree on including a THEW session in this year program during which the most interesting works base on the THEW database will be presented.
This year the meeting is held in Belfast (UK), it is hosted by the University of Ulster. You can find more information about the meeting at: http://www.cinc2010.org .

jean

THEW Team: Jean Xia, Software Engineer

Jean Xia was born in China, and came to the United States to continue her education in 1993. She received her masters degree in Biophysics and Computer Science from the University of Rochester and Rochester Institute Technology in 1996 and 2001, respectively. In 2001, she joined the Clinical Cardiovascular Research Center as a software engineer. During the past nine years, she developed research software and several programs for supporting various researches in Dr. Couderc's lab. Now she is a part-time PhD student in the Department of Electrical and Computer Engineering at University of Rochester. Her responsibilities in the THEW organization are to develop software to support client application, convert ECG files into THEW repository compliant format and ensure technical support to THEW users.