New Members

[07/20/2017], University of Central Florida , Orlando,, USA, The Advanced Research Computing Center (ARCC) at the University of Central Florida houses high performance computing resources for use in research by faculty across campus. Research supported by the ARCC covers a variety of different disciplines, including Engineering, Modeling and Simulation, Optics, Nanoscience, and many others. The ARCC staff also pursues research in machine learning and visualization, as well as information technology. Currently, the center houses a high performance computing system known as Stokes, which is used to help support and drive research within the university.

[05/02/2017], Shandong University, Shandong Sheng, China Founded in 1901, Shandong University, based in Jinan, China, is the nation’s largest public university. It has prepared over 400,000 individuals in a variety of specialties, and has been making significant contributions to the country’s economic and social development. The growth of the university has allowed it to rise to the forefront of many fields in China. They continually develop new disciplines such as crystal materials, cardiovascular functional recovery, and new drug manufacturing to stay on the cutting edge of scientific research. Many of these newly formed disciplines have quickly risen to the first-class level within the country, and some are even know abroad.

[02/17/2017], University of Porto, Praça de Gomes Teixeira, Portugal The University of Porto, founded in 1911, is a leading scientific and research institution located in Portugal. The university is internationally recognized for the quality of research it produces, and is consistently ranked among the 150 best European universities. It is an important driver of economic, social, and scientific development within Portugal, and strives to be a strong partner of the business community. By combining quality teaching with a focus on market needs, the university strives to actively participate in, and encourage, the progress of communities in which it operates.

[05/24/2016], Marche Polytech University, Ancona, Italy, The Department of Life and Environmental Sciences was established in 2011 by merging a number of laboratories involved in a wide spectrum of fundamental and applied research topics. The department is a center of excellence of the Università Politecnica delle Marche and includes more than 100 scientists and technicians that conduct research in areas such as analytical and organic chemistry, biophysics, cellular and molecular biology, biochemistry and genetics, microbiology and biotechnology, viral, prokaryotic, fungal, algal, plant and animal systematics, physiology and reproduction, marine biology, ecology, eco-toxicology, oceanography, Earth sciences, risk reduction and civil protection.

[05/12/2016], University of Buenos Aires, Buenos Aires, Argentina, Buenos Aires University consists of thirteen colleges/schools, dozens of research institutes, and two secondary schools, offering more than 100 undergraduate majors. There is a teaching staff of 30,000 teachers, and approximately 300,000 students; 30% of scientific research in Argentina takes place at UBA. Standard undergraduate studies last approximately 5 years. Buenos Aires University offers several graduate programmers, masters, PhDs, and specialization courses as well.

[05/12/2016], Queen's University, Kingston, Canada, The mission of Queen's University has been articulated in a number of different forms and formats over the past decade. In all of the presentations, the key elements have remained constant: The University will build on the strength that is Queen's - students, faculty, staff and alumni - to be among the best of internationally known universities in Canada, recognized for: •the exceptional quality of undergraduate and graduate students and programs in the arts, sciences and professions; •the intellectual power and value of research and scholarship by faculty members and students; •the exemplary service of the University and that of its graduates to the community and the nation and the community of nations.

[04/28/2016], University of Leuven, Leuven, Belgium KU Leuven is a research-intensive, internationally oriented university that carries out both fundamental and applied research. It is strongly inter- and multidisciplinary in focus and strives for international excellence. To this end, KU Leuven works together actively with its research partners at home and abroad.KU Leuven encourages personal initiative and critical reflection in a culture of idea exchange, cooperation, solidarity and academic freedom.

[03/07/2016], Mayo Clinic , Rochester, MN,, USA, Mayo Clinic is the first and largest integrated nonprofit medical group practice in the world, employing more than 3,800 physicians and scientists, as well as 50,900 allied health staff. Based out of Rochester, MN, the Mayo Clinic’s mission is “to inspire hope and contribute to health and well-being by providing the best care to every patient through integrated clinical practice, education, and research.” The practice specializes in treating difficult cases through tertiary care, and spends over $500 million a year on research. It was also recognized as one of the best hospitals in the U.S. for 2015-2016 by U.S. News & World Report.

[03/02/2016], Czech Technical University, Prague,, Czech Republic, The Czech Technical University in Prague (CTU) is an internationally recognized higher education and research institution with more than 300 years of tradition and excellence. CTU is a leading technical research university with a large focus on cutting edge science and engineering, paired with a high-quality technical education. With 8 departments each focused on an engineering specialty, the university educates modern specialists, scientists, and managers who are dynamic, flexible, and able to rapidly adapt to the requirements of the market.

[02/10/2016], CERB , Baugy,, France, Located in Baugy, France, CERB was founded in 1973 and has developed into a leading international contract research organization (CRO) in the fields of pre-clinical pharmacology and toxicology. Taking on the challenges of modern drug development, CERB has created a distinctive image as a leading major service provider to the pharmaceutical industry in the context of innovative bio-medical research. CERB takes advantage of its sophisticated synergy between pharmacology and toxicology resources to provide complete pre-phase I packages for new molecules in an economic and timely manner

[01/07/2016], Goergen Institute for Data Science (GIDS), Rochester NY, USA The GIDS supports faculty research, particularly collaborative public-private research partnerships spanning several domains, such as developing health care breakthroughs, improving our knowledge of how the brain works, and creating tools and systems to efficiently use data. The GIDS is working to build strategic alliances and business partnerships among the academic, government, and business communities, leveraging University of Rochester expertise.

[10/06/2015], Dresden University of Technology, Dresden, Germany, Dresden University of Technology is one of eleven German universities that were identified as an “excellent university", and includes over 37,000 students with 14 institutions offering a wide range of academic programs. The Institute of Biomedical Engineering focuses on the early detection, diagnosis, and treatment of life-threatening cardiovascular disease. With a strong focus on research.

[10/06/2015], Biomedical Systems, St. Louis, MO , USA, Biomedical Systems has set the health care industry standard by providing innovative approaches to non-invasive diagnostic services, clinical trials, and products. They provide their clients with the ability to increase cost efficiencies and bring studies to database lock on an advanced timeline by combining over 20 modalities in one study. Biomedical Systems' pioneering spirit is based on a strong history as a privately held company that focuses on clients and people.

[09/15/2015], VivaQuant LLC, St. Paul MN, USA, VivaQuant provides products, services and technology that incorporate advanced signal processing to more accurately extract valuable information from biological signals. Through their technology they are committed to improving the lives of patients and the productivity of clinicians and researchers.

[08/04/2015], Sensium Healthcare Ltd, Oxfordshire, United Kingdom Sensium Healthcare, A global pioneer in wireless monitoring of vital signs. The company focus is on ultra-low power, lightweight, monitoring solutions which improve patient care and safety,shorten hospital stays and reduce healthcare costs.

[07/28/2015], Seoul National University, Gwanak-gu, South Korea, Seoul National University, As Korea leading research university, honoring the ideals of a liberal education aim at teaching students a lifelong love of learning that will form the basis for continuous personal growth. It includes 16 Colleges, 1 Graduate School, 9 Professional Graduate Schools with 16,006 Undergrad Students, 10,559 Graduate Students.

[07/16/2015], Boston Scientific, Marlborough, MA, USA, A leading innovator of medical solutions that improve the health of patients around the world. Products and technologies used to diagnose or treat a wide range of medical conditions, including heart, digestive, pulmonary, vascular, urological, women health and chronic pain conditions. Boston Scientific is dedicated to transforming lives through innovative medical solutions that improve the health of patients around the world.

[09/30/2014], Harvard Medical School-Wyss Institute for Biologically Inspired Engineering, Boston, USA, The Wyss Institute aims to discover the engineering principles that Nature uses to build living things, and harnesses these insights to create biologically inspired materials and devices that will revolutionize healthcare and create a more sustainable world. In medicine, the Institute is developing innovative materials, devices, and disease reprogramming technologies.

[03/12/2014], University Medicine Berlin, Bonn, Germany, The Charite is one of the largest university hospitals in Europe. Here, 3700 doctors and scientists heal, do research and teach at the top international level. More than half of the German Nobel Prize winners in medicine and physiology come from the Charite, among them Emil von Behring, Robert Koch and Paul Ehrlich.

[01/23/2014], BioSign GmbH, Ottenhofen, Germany, Developing innovative measurement and therapy systems for professionals and end-users in the subject area vegetative (autonomic) nervous system. BioSign is responding to the growing medical recognition that disturbances in the autonomic nervous system and disturbances in the interplay of the various organs are involved with the autonomic nervous system.

[11/14/2013], University of Rochester, Computer and Electrical Engineering, Rochester, NY, USA. This department has multiple programs related to energy, to health and medicine, to the connected world, and to music. Specific research programs span a wide range, including medical imaging, image processing, genomics, audio and music signal processing, among others.

[10/31/2013], RIT, Microsystem Engineering, Rochester, USA The multidisciplinary program builds on the fundamentals of traditional engineering and science including the manipulation of electrical, photonic, optical, mechanical, chemical, and biological functionality to process, sense, and interface with the world at a nanometer scale.

[09/10/2013], Medtronic, Inc., Mounds View, USA Medtronic develops and manufactures innovative medical device technology and therapies to treat chronic disease worldwide.

[06/11/2013], RIT, Department of Biomedical Engineering, Rochester, USA The RIT mission is to provide technology-based educational programs for personal and professional development. We rigorously pursue new and emerging career areas. We develop and deliver curricula and advance scholarship relevant to emerging technologies and social conditions. Our community is committed to diversity and student centeredness and is distinguished by our innovative and collaborative spirit.

[05/02/2013], Masonic Medical Research Laboratory, Utica, NY, USA The Masonic Medical Research Laboratory is a not-for-profit institute dedicated to improving the health and quality of life for all. The Laboratory primary mission is to conduct high quality basic and clinical research aimed at generating knowledge and information necessary for development of the medical cures and treatments of tomorrow.

[04/22/2013], Universitat Politecnica de Catalunya (Barcelona-Tech), Barcelona, Spain. The Universitat Politecnica de Catalunya (UPC): BarcelonaTech is a public institution dedicated to higher education and research, specialised in the fields of engineering, architecture and science. With a focus on intellectual rigor, critical thinking, a transversal approach to knowledge, educational innovation and entrepreneurship, the UPC produces competent professionals with the skills they need to tackle present and future challenges.

[03/20/2013], Teschnische Universitat(TU), Dresden, Germany. The TU Dresden is one of eleven German universities that were identified as an Excellence University. TUD has about 36.500 students and almost 5319 employees, 507 professors among them, and, thus, is the largest university in Saxony.

[02/08/2013], Baskir State Pedagogical University (BSPU), Ufa City, Russia M. Akmullah BSPU is a large scientific, educational, cultural and social center of the Republic of Bashkortostan. It includes the Institute of Pedagogics, the Institute of Professional Education and Information Technologies, the Institute of Historical and Legal Education, the Institute of Philological Education and Cross-Cultural Communication and 7 departments with about 12 000 students.

[02/01/2013], Chung-Yuan Christian University, Taiwan, China Chung Yuan Christian University is founded on the spirit of Christian love for the world. With faith, hope, and love, we endeavor to promote higher education for the benefit of the Chinese people, aiming at the pursuit and advancement of genuine knowledge in order to maintain our cultural heritage and, thus, to serve humankind.

[12/11/2012], Cardio-QT Ltd., Glasgow,, United Kingdom Headed by Royal College Accredited Cardiologist and Bioengineer supported by PhD Scientists, Cardio-QT Ltd is an award winning, highly innovative Core Cardiac Analysis Laboratory offering an array of sophisticated validated techniques to solve all analytical research problems.

[10/21/2012], National Polytechnic Institute of Mexico, Mexico City,, Mexico The Institute is the State secular free education institution, guide of public technological education in Mexico. A leader in the generation, application, dissemination and transfer of scientific and technological knowledge.

[09/24/2012], Massachusetts General Hospital, Harvard Medical School , Charlestown, MA,, USA Mass General has long been a leader in successfully bridging innovative science with state-of-the-art clinical medicine. With an annual research budget of nearly $764 million, Mass General conducts the largest hospital-based research program in the United States - a program that spans more than 20 clinical departments and centers across the hospital. This funding drives discoveries and breakthroughs in basic and clinical research, which translate into new and better treatments that transform medical practice and patient care.

[05/24/2012], College of Veterinary Medicine, Cornell University, Ithaca, NY,, USA The mission of the Department of Biomedical Sciences is to educate and inform the veterinary and human biomedical communities through our diverse research and clinical service excellence as well as through our commitment to undergraduate, graduate, and veterinary teaching.

[05/02/2012], The Victor Chang Cardiac Research Institute (VCCRI), Sydney, Australia The VCCRI is committed to excellence in research into heart disease and cardiovascular biology, cardiovascular research training, and facilitating the rapid application of research discoveries to patient care.

[02/09/2012], SAIT, Samsung Advanced Institute of Technology, Gyeonggi,, Korea SAIT provides a full spectrum of support so its researchers can focus on creative research, seek the convergence of heterogeneous technologies and take up new challenges. Meanwhile, SAIT also actively engages in "open innovation" to jointly create future value with other research institutions through collaboration.

[01/26/2012], FDA-CDRH: Center for Devices and Radiological Health, Silver Spring, MD, USA FDA Center for Devices and Radiological Health (CDRH) is responsible for regulating firms who manufacture, repackage, relabel, and/or import medical devices sold in the United States. In addition, CDRH regulates radiation-emitting electronic products (medical and non-medical) such as lasers, x-ray systems, ultrasound equipment, microwave ovens and color televisions.

[01/10/2012], Department of Physiological Nursing, University of California, San Francisco, CA, , USA The Mission of the Department of Physiological Nursing prevention of UCSF is to study the prevention, measurement, and treatment of physiological and biobehavioral responses to health, illness/disease and aging. Psycho-physiological interrelationships and interventions also are studied. Research spans all phases of the health/illness trajectory including people who are healthy, critically ill, living with a chronic illness, and those at the end of life.

[01/03/2012], University of Bologna (HST-ICIR) , Bologna,, Italy The University of Bologna was probably the first University in the western world. Its history is one of great thinkers in science and the humanities, making it an indispensable point of reference in the panorama of European culture. Bologna has thus been called upon to forge relationships with institutions in the most advanced countries to modernise and expand its activity. Among the many challenges which it has met with success, Bologna committed itself to the European dimension which has now led to adoption of the new university system.

PRESS CENTER

[09/23/2010]: AstraZeneca joins the THEW to further cardiac safety inThe Medical News: here.

[12/16/2009]: The Director of the THEW interviewed by Technology Review published by the MIT: here.

[11/11/2009]: New Research Center to Focus on Cardiac Safety and Innovation in Pharmaceutical Industry Today: here.

[6/11/2009]: University of of Rochester and FDA Partner for ECG Database, Drug Discovery & Development Magazine. More info here

[5/6/2009] FDA website Existing Partnerships FDAs Public-Private Partnership Program: THEW

[03/28/2009] Public and Private part- nership to help determine Clinical Biomarker Utility in Applied Clinical Trials online.com.>here

Newsletter Issue 11, April 2011

New database: High-resolution ECG from 927 consecutive patients referred

for exercise and myocardial perfusion single photon emission computed tomography (SPECT)

thewNews


Editorial by JP. Couderc, PhD

In this first THEW Newletters of the year, we describe the most important developments of our initiative between December 2010 and March 2011. First, the THEW IT hardware has been physically moved to the University Enterprise Center, a $20M fully-secured computing center managed by the University of Rochester. We describe this new site for the THEW data in the first article. In addition to its high-level security, this organization provides full 24-hour support to our Center with unlimitted access to storage space and high-speed network. Second, we are glad to continue to expand the THEW with a novel dataset of ~20-minute continuous 12-lead ECGs from 927 patients recorded during stress test (Bruce protocol). This new set of recordings is described in details below, it includes full beat annotations which have been manually reviewed and adjusted by the THEW ECG technicians. In addtion to the high-frequency ECG signals, the myocardial perfusion scores are available in the associated THEW clinical database. Third, we are glad to have our expert opinion section covered by Dr. Guy Amit (Biological Signal Processing Ltd., Tel-Aviv, Israel) presenting the high-frequency QRS analysis technology developed and validated using these 927 patients. Finaly, we would like to welcome our new academic members that include Johns Hopkins School of Medicine, the Academy of Medical Sciences of China, the School fo Computing and Mathematics from the United Kingdom, and finaly the Department of Electrical and Electronic Engineering from the University of Melbourne, Australia.

We hope you will enjoy this Newsletter and please do not hesitate to contact our group if you have any questions.


New THEW servers hosted by the University Enterprise Computing Centertech

The hardware of the THEW repository has been moved to the University Of Rochester Enterprise Computing Center (ECC). The ECC is a $20M computing center declared "operationally stable" on June 4, 2009 after intense testing. One half of the facility (approx 21,000 sq ft) was reconstructed to support an 8000 sq ft datacenter. The primary data center is staffed 24 hour per day, 365 days per year. It is classified as: - Uptime Institute Tier III: composed of multiple active power and cooling distribution paths, but only one path active, has redundant components, and is concurrently maintainable, providing 99.982% availability- Bruns – Pac – Reliability 8: Reliable Redundant Data Center with dedicated power and cooling systems, redundant UPS systems, redundant dedicated A/C units and redundant generators The ECC has redundant fiber optic cables into the facility on diverse paths from two directions. Each fiber path terminates in the data center on redundant optical nodes. Systems are backed up to tape each day to an offsite backup location – Open system backups are not made at, or retained at the center. Tapes are stored in a University tape vault, secured by card swipe and video surveillance and monitored 24x7x365 by Data Center personnel. The Data Center Operations maintains a complete set of operating processes and procedures in both hardcopy and electronic formats. Data Center requires change control processes for all hardware and software modifications. This process is documented in the ISD or UnivIT Change Management Procedures The physical security of the building is ensured by card access swipe systems at all perimeter exterior doors and all interior doors within the data center space (raised floor, mechanical and electrical).Video intercom at all perimeter doors connected directly to Operations Command Center. Video surveillance monitoring covers 100% of the building's exterior, as well as interior monitoring of all common areas and raised floor space. Video is digitally recorded and retained for 15 days. University Security road patrols visit the center on a non-standard schedule multiple times each day, 24 hours per day 365 days per year. The ECC hosts digital information from clinical trials in collaboration with pharmaceutical companies.


New Database: 927 high-resolution ECGs from patients undergoing exercise-testing available in the THEW

growthThis database includes 927 consecutive patients referred for exercise myocardial perfusion single photon emission computed tomography (SPECT) in two medical centers (Assuta Medical Center, and Sheba Medical Center). Exclusion criteria were cardiac pacemaker, atrial fibrillation at the time of testing and QRS duration ≥ 120 msec. The exercise protocol was as follow: beta blockers and calcium channel blockers were discontinued at least 48 hours before testing. A symptom-limited treadmill exercise test was performed using the Bruce protocol. High resolution 12 lead ECG (HyperQ™ Stress System, BSP Ltd, Tel Aviv, Israel) was continuously recorded throughout baseline, exercise and recovery phases. ECG acquisition was performed at a rate of 1000 samples/second using 16 bit resolution (measurement sensitivity < 0.15µV), with an analog frequency response of 0.05 to 125Hz. Conventional ECG monitoring during the exercise test was either extracted automatically from the high resolution ECG traces or acquired using an additional ECG device (Q-Stress, Quinton Inc, WA), using a second set of 10 electrodes.

The patients underwent either stress/rest 99mTc-sestamibi gated SPECT, or stress/ redistribution 201Tl SPECT. 

The 99mTc-sestamibi protocol: a dose of 10 mCi 99mTc-sestamibi was injected at peak stress, and exercise was continued for an additional minute at peak stress, and two minutes at one lower exercise level. Gated SPECT acquisition was initiated 15-30 minutes later, using a 90° dual-detector gamma camera (Axis, Philips Medical Systems, Cleveland, OH, or CardiaL, GE Healthcare, Israel) equipped with LEHR collimators. Acquisitions were performed using 60 projections, 30-33 sec/projection, over 180° circular orbit. ECG gating was performed using 8-frames and a 100% acceptance window. Resting images were acquired 3.5-4 hours later, one hour after injection of an additional 30 mCi 99mTc-sestamibi, over 23-26 sec/projection.


The 201Tl protocol: a dose of 2.8-3.5 mCi 201Tl (adjusted to patient weight) was injected at peak exercise. SPECT acquisition was started 8-12 minutes following stress, using a 90° dual-detector gamma camera (Axis, Philips Medical Systems, Cleveland, OH, CardiaL, GE Healthcare, Haifa, Israel or Varicam, GE Healthcare, Haifa, Israel) equipped with LEHR collimators. Acquisitions were performed over 180° circular orbit using 60 projections, 22-26 sec/projection at Assuta Medical Center or 30 projections, 40 sec/projection at Sheba Medical Center. Redistribution images were acquired 3-4 hours later using 60 projections, 25-29 sec/projection at Assuta Medical Center or 30 projections, 40 sec/projection at Sheba Medical Center. Reinjection of 0.5-1 mCi 201Tl was administered whenever a severe perfusion defect was identified in the stress images. Images were reconstructed using filtered back projection, with a Butterworth post-filter. No attenuation or scatter correction was applied at Assuta Medical Center; attenuation correction was applied at Sheba Medical Center.

Perfusion images were visually scored using a 20-segment model of the left ventricle and a 5-point scale (0=normal tracer uptake, 1=mildly reduced, 2=moderately reduced, 3=severely reduced, 4=no uptake) (2). This analysis was performed by expert interpreters (TS or PC), over-riding automatic segmental scores, obtained by commercial software (QPS, Cedars Sinai Medical Center, Los Angeles, CA). The summed stress score and summed rest score were calculated as the sum of the individual segment scores for the stress and rest images and converted to percent total myocardium (% myocardium) by dividing by 80 (maximal potential score = 4 × 20). The amount of ischemic myocardium (IM) was calculated as the summed difference score (the difference between summed stress and summed rest scores) divided by 80. Patients were classified as: no ischemia or equivocal (IM<5%), mild ischemia (5%≤IM<10%) and moderate/severe ischemia (IM≥10%) (3, 4).

References available here.


High-Frequency QRS Analysis: From the Research Lab to the Clinical Market

By Guy Amit, PhD., Biological Signal Processing Ltd., Tel-Aviv, Israel

Ischemic heart disease (IHD) is a major healthcare problem worldwide. In the US alone, there are 1 7 . 6 million IHD patients, and the estimated annual incidence of new and recurrent myocardial infarction is estimated to be 935,000 (1). ECG retains its central role as the first-line diagnostic modality for ischemic heart disease workup in both chronic and acute presentations. Electrocardiographic detection of myocardial ischemia is typically based upon identification of repolarization abnormalities, manifested as changes in the ST-T segment. However, ischemia also induces changes during the depolarization phase, which can be detected and quantified by analyzing the high-frequency components of the QRS complex (HFQRS). HFQRS components are very low in amplitude and are typically filtered out by conventional ECG devices. The HFQRS signal originates from the fragmentation of the electrical activation wavefront in the myocardium, caused by the branching nature of the conduction system. In ischemic regions of the myocardium, local slowing of conduction velocity reduces the wavefront fragmentation, causing changes in the intensity and morphology of HFQRS signals (2). Over the last 30 years, HFQRS have been extensively studied in computer simulations, animal models, humans during coronary balloon occlusion and patients undergoing exercise test (2-7). Analysis of HFQRS has been reported to be more sensitive and specific than conventional ECG interpretation in detecting exercise-induced ischemia (5-7). Recently, Biological Signal Processing Ltd. (BSP) has introduced the HyperQ™ EX300 stress system, which provides automated HFQRS analysis in a commercially-available exercise ECG system. The system's technology is based upon sophisticated signal processing algorithms that perform accurate QRS alignment and averaging, band-pass filtering in the frequency range of 150 to 250 Hz, and computing of the root-mean-square intensity of the HFQRS signal. The trend of HFQRS intensity in 12 leads throughout the exercise test is then examined, and the relative intensity reduction is used as an index of ischemia (Figure 1).

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FIGURE 1:

Figure 1: Example of conventional ECG and HFQRS obtained in an ischemic patient (top), and the HFQRS analysis provided by the HyperQ EX-300 system (bottom). Note the marked reduction in HFQRS intensity with exercise. (click to enlarge)

The HyperQ index of ischemia was studied in 996 patients (age 58.9±10.2 years, 670 men), referred for exercise nuclear scan, which was used as the gold standard of ischemia. HyperQ response correlated with severity of ischemia, and was more sensitive (69% vs. 39%, P<0.005) and more specific (86% vs. 82%, P<0.05) than ST segment analysis. Multivariate logistic regression indicated considerable incremental diagnostic value of HyperQ over pre-test likelihood of CAD and exercise parameters (7).
Ongoing research efforts are aimed to establish HFQRS analysis as a routine adjunct to workup of IHD, and to develop new clinical applications of the technology. Of particular interest are the utilization of HFQRS for early detection of acute myocardial ischemia in patients presenting with chest pain, continuous monitoring of patients in risk of transient ischemic episodes and identification of ischemia from intra-cardiac pacing leads.

References

  1. Lloyd-Jones D et al. Heart Disease and Stroke Statistics--2010 Update. A Report From the American Heart Association. Circulation 2010; 121:e46-e215.
  2. Abboud S et al.. Simulation of high-resolution QRS complex using a ventricular model with a fractal conduction system. Effects of ischemia on high-frequency QRS potentials. Circ Res 1991;68:1751-1760.
  3. Abboud S. Subtle alterations in the high-frequency QRS potentials during myocardial ischemia in dogs. Comput Biomed Res 1987; 20(4):384-395.
  4. Abboud S et al. Detection of transient myocardial ischemia by computer analysis of standard and signal averaged high frequency ECG in patients undergoing percutaneus transluminal coronary angioplasty. Circulation 1987;76:585-96.
  5. Pettersson J et al. Changes in high-frequency QRS components are more sensitive than ST-segment deviation for detecting acute coronary artery occlusion. J Am Coll Cardiol 2000;36:1827-34
  6. Toledo E et al. Detection of Stress-Induced Myocardial Ischemia from the Depolarization Phase of the Cardiac Cycle - A Preliminary Study. J Electrocardiol 2009; 42:240-9
  7. Sharir T et al. Detection of Stress-Induced Myocardial Ischemia Using Analysis of Depolarization Abnormalities. J Am Coll Cardiol 2009;53:A297

Patricia Cermark: maintaining the THEW database for members' information and email communications

PCPatricia Cermak is a native of Penn Yan, N.Y.  and is a graduate of Rochester Business Institute with a degree in Secretarial Science.  Pat came to the University fo Rochester Medical Center in 2006 after working 30 years for Rochester's Eastman Kodak Company.  Pat is involved in the maintenance of the THEW member database.